In order to increase the retention of compounds, C18 Columns often need to be used in high aqueous phases or even 100% aqueous phase, and use in high aqueous phase for a long time easily lead to hydrophobic collapse .Gold RP18 Plus can effectively use the hydrophilic effect of polar groups by embedding a polar group within the octadecyl chain, making it compatible with and resistant to 100% aqueous phase, and at the same time shielding the residual silanol group effect on the surface of the silica .Gold RP18 Plus can reduce trailing of basic compounds, and provides selectivity different from that of C18.
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